Effect of addition of cosurfactant on the phase behaviour of. To differentiate within the two phase region and single phase region in the ternary diagram. Physical stability of the formulations were checked by. The values of f a reported in table 1 clearly indicate that the systems with higher surfactant content have a much higher amphiphilic strength and thus are also expected to form more highly structured microemulsion as seen in fig. This app, based on unpublished work by acosta, was a groundbreaking development. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. Formulation and evaluation of microemulsion based gel of. The microemulsion mixture containing 35% wt soybean oil, 5% wt. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex.
The presence of nacl decreases the domain size of 1. Design and formulation of optimized microemulsions for. In this study, the effect of several shortchain alcohols on pseudoternary phase diagrams composed of. To develop microemulsion based hydrogel of voriconazole was for effective treatment of skin mycosis. The below shows a hypothetical ternary phase diagram of a microemulsion. Pseudoternary phase diagrams were used for the selection of microemulsion area. Pdf the purpose of this study is to give an insight into the significance of. Phase diagrams of wo microemulsion stabilised by nonionic. At 45% wtwt surfactant system, microemulsions containing various ratios of water. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. The studies were performed employing conductometric titrations, differential scanning calorimetry. The compositions of microemulsion were selected from the pseudoternary phase diagram which had the largest microemulsion region.
Preparation of nano and microemulsions using phase inversion. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity, viscosity, differential scanning calorimetry dsc, cryofield emission scanning electron microscopy cryofesem and. Thermodynamic stability studies the thermodynamic stability of gliclazide microemulsion was evaluated using following stress tests in series. Research article evaluation of combination drugs before the. Prediction of the phase diagram with a modi ed helfrich free energy harsha mohan paroor max planck institute for polymer research mainz, germany and johannes gutenberg university, mainz, germany.
Characterization of microemulsion structures in the. A journey through the phase diagram of a pharmaceutically. The first and second corners represented 100% of oo and w, respectively while the third corner referred to 100% of a binary mixture of smo and psmo. Prediction of the phase diagram with a modi ed helfrich free energy harsha mohan paroor max planck institute for polymer research mainz, germany and johannes gutenberg university, mainz, germany a thesis submitted for the degree of doctor of philosophy in natural sciences may 2012. Jul 24, 2015 the use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. International research journal of pharmaceutical and applied. The pseudoternary phase diagrams were constructed by drop wise addition of double distilled water to. Preparation of nano and microemulsions using phase. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram article pdf available in advanced pharmaceutical bulletin 22. Microemulsion preparation a pseudoternary phase diagram was constructed using the aqueous phase titration method by o opti 20.
The pseudoternary phase diagrams were constructed by drop wise addition of double distilled water to homogenous liquid mixture of oil, surfactant. Construction of pseudoternary phase diagrams selfemulsifying drug delivery system sedds containing art and lmf was formulated by pseudoternary phase diagram using water titration method. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Construction of pseudoternary phase diagram and its evaluation. Investigations into the formation and characterization of phospholipid microemulsions. International research journal of pharmaceutical and.
Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region. Jun 01, 2011 figure 2 shows a pseudoternary phase diagram for mixtures of palm kernel oil esters, tween 80, and water at various component compositions. Prapaporn boonme, duangkhae maneenuan and wibul wongpoowarak. Emulsions part 3 microemulsions miniemulsions remarks to. However, it constructs a microemulsion and lamellar phase in a phase diagram without cosurfactant only at a narrow range of composition. Pseudoternary phase diagram, selfdispersible formulation, hydrophobic drug, oral. The phases include conventional emulsion, gel viscous and transparent translucent microemulsion. Pseudoternary phase diagrams of a drug delivery system. Preparation of nicotinamide microemulsions and formulation.
Microemulsions were then spontaneously prepared by mixing o. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. Given the three generic binary mixtures phase diagrams, the phase diagram for the ternary abc mixture is discussed next. Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. The stability ranges of microemulsions in systems containing soybean lecithin, alcohol, water, and. The phase behavior can easily report on pseudoternary triangles. The nanoemulsion region was determined by constructing a pseudoternary phase diagram using the water titration method 22. Apparently, a fixed weight or volume ratio must be selected. Transdermal delivery enhancement of carvacrol from origanum. Design and formulation of optimized microemulsions for dermal.
The use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. Screening pesticide of betacypermethrin emulsion in water. Ternary phase diagram for a ternary system chapter 10. Evaluation and optimization of waterinoil microemulsion using. Pseudoternary phase diagram of microemulsion composed openi. This article is from jundishapur journal of natural pharmaceutical products, volume 8. The ac binary phase diagram shows three critical points. In this work, a pseudoternary phase diagram was designed by using soybean oil nonpolar phase, ethanol polar phase, 2butanol cosurfactant c and dbb 7104 surfactant s, and the microemulsion region was identified as a biofuel. To play with that variable you can set a negative hld first and take a look at the height of the vertex of that system as you increase the length of the surfactant. In this study, the effect of several shortchain alcohols on pseudoternary phase. Ternary phase diagrams institute for advanced study. Cosurfactants were added to obtain nanoemulsion systems at low surfactant. Construction of pseudoternary phase diagram is an important tool for screening of. Transdermal delivery enhancement of carvacrol from.
At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity. Throughout the article, two distinct gels, made of two different microemulsion droplets r. The wo and ow microemulsion formulations were designated as. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. All types of dispersions, including conventional waterinoil and oilinwater emulsions, waterinoil and oilinwater microemulsions, bicontinuous and transitional liquid crystalline structures with. It could be noted that the area of microemulsion region was considerably large since 1butanol acted as a cosurfactant and. Since the identification of microemulsions by schulman. The different phases correspond to the different ways in which the copolymer can move through the microemulsion.
Preparation and characterization of nicotinamideloaded microemulsions 35 3. Pseudoternary phase diagrams and formulation of microemulsion of lornoxicam almond oil oil, tween 20 surfactant, dmso cosurfactant were used for formulation of microemulsion using water titration method. Characterization of microemulsion structures in the pseudoternary. In one app it is possible to see how the oil and water phases behave, as 2 phase or 3 phase systems. Pseudoternary phase diagram construction to investigate concentration range of components for the existing boundary of microemulsion regions, pseudoternary phase diagrams were constructed using the water titration method. Pdf construction of pseudoternary phase diagram and its. We obtain the general structure of the phase diagram, and state a number of properties that exhibit the ne structure of the phase diagram as well. Pdf identification of phases of various oil, surfactant. Finding the amounts of phases in a two phase region. An extensive investigation of the pseudoternary phase diagram of mixtures of water, isopropyl palmitate, polyoxyethylene 10 oleyl ether brij 97 c 18 e 10, and butanol is presented for two different cosurfactant concentrations, thereby varying the hydrophilicity of the amphiphile. Apparently clear single phase formulations can still consist of multiple isotropic phases e. Formula optimization design of pesticide microemulsion. The influence of drug loading level on the phase diagram was also determined. The influence of the drug on microemulsion area was observed.
Phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Phase behavior of pseudoternary brinealkanealcohol. They have concluded that the interaction between water and oil domains is an important parameter affecting the stability of microemulsions roux et al. A pseudoternary phase diagram was constructed using water titration method.
To differentiate within the twophase region and singlephase region in the ternary diagram. The latter come in the form of theorems and conjectures. The phase behavior of nonionic and anionic surfactants along with different combinations of the two were determined,different solvent,the contents of active ingredient in oil,different water hardness were investigated using pseudoternary phase diagram with betacypermethrin as the pesticide. The size area of the microemulsion region of the phase diagram was found to be. The microemulsion regions were defined as ow or ow type according to oil and water weight ratios. Lecithin is a natural amphiphilic molecule, the microemulsions of which are often employed as a transdermal delivery medium of drugs and cosmetics. Pdf study of pseudoternary phase diagram behaviour and the. Microemulsion based formulation as drug delivery system. The optically transparent single phase microemulsion can be formed in the region enclosed by. Aminosilicone oil microemulsion,cosurfactant, phase diagram. The fish phase diagram is obtained when an mc cut is.
Usually have elements at the corners as the constituents. Isotropic mixture of oil, surfactant, cosurfactant, and drugs was formed. Design and optimization of chlordiazepoxide solid self. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion. Pdf preparation and characterization of dexamethasone. Using algebraic geometry to describe boundaries of microemulsion. Construction of pseudoternary phase diagram is an important tool for. Development and optimization of microemulsion formulation. The singlephase boundary line is found on any section that. The supercritical and the subcritical phase diagram each have two localized phases and two delocalized phases, separated by four critical curves meeting at a quadruple critical point. For oral bioavailability enhancement of glipizide biresh k sarkar1, shiv s.
Microemulsion how to construct ternary phase diagram anyone provide step by step tutorial. A system consisting of water, oil, surfactant or surfactants mixture with various phases may be depicted on a phase tetrahedron whose apexes, respectively, present the pure components. The pseudoternary phase diagram of each system was constructed on a triangular graph to obtain microemulsion region. Its phase diagram can be used as a guide for the selection of different microemulsion compositions for hydrothermal synthesis. The fish phase diagram is obtained when an mc cut is taken across the abc triangle phase diagram. Research article evaluation of combination drugs before. The critical points between microemulsion region and other phase regions were determined when the appearance of the system changed from clear to turbid, and vice versa. Pseudoternary diagram of an oilinwater propofol microemulsion of propofol oil, purified poloxamer 188 nonionic surfactant, and sodium caprylate ionic cosurfactant. Pseudoternary phase diagrams of systems containing. As a consequence, phase diagrams based on two different types of small molecule surfactants tween 20 or tween 80 were constructed which define the ratios of three components in the composition of the ternary mixtures that allow the formation of oilinwater ow or waterinoil wo nano. The increased incidence of inflammatory diseases has. Effect of shortchain alcohols as cosurfactants on pseudo. Another important variable that influences the shape of the ternary phase diagram is the length of the surfactant tail l.
Preparation, optimization and characterization of microemulsions 167 5. Phase diagrams of wo microemulsion stabilised by non. The suitability of amounts of surfactant, cosurfactant, oily, and aqueous phases for formulation of oilinwater ow type mes was confirmed by initial. Nov 21, 2014 phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Fraction of a phase is determined by taking the length of the tie line to the phase boundary for the other phase, and dividing by the total length of tie line. Various mes were selected from the pseudoternary phase diagram with 3. It is the boundary line around that singlephase region. First, pseudoternary phase diagrams of water or brine decanedodecanesulfonatesbutan1ol. Note that the lower ucst may lie below the freezing point of the mixture. Preparation and evaluation of tretinoin microemulsion. Pseudoternary phase diagrams of water, oil and ssmix of. Nmr characterization and transdermal drug delivery potential of microemulsion systems. In two phase region draw the tie line or isotherm 3. The phases include conventional emulsion, gel viscous and transparenttranslucent microemulsion.
Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudocomponent. Optimized microemulsion batches were selected through pseudoternary phase diagram using oleic acid, tween 80 and ipa as oil, surfactant and cosurfactant, respectively followed by stability studies and characterization. Isopleth through hypothetical ternary phase diagram at a constant. The results showed that the area of ew was affected slightly by the nonionic surfactants and anionic. College of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh, india. Mpde practical surfactants science prof steven abbott. Pseudoternary phase diagrams of water, oil and s smix of. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex and protruding towards the wateroil axis.1236 1591 869 229 1372 1261 837 871 779 25 209 81 1617 1475 463 733 194 830 450 1367 1379 673 533 226 963 1159 1600 1583 18 1387 73 1544 926 596 1420 1391 961 1287 1144 683